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Sunday, February 1, 2009

Poxviridae

There are 2 types of Poxviridae:
§ Chordopoxvirinae – ( poxvirus of vertebrates)
§ Entomopoxvirinae – ( poxviruses of insects)

Picture of smallpox under microscope!!

There are 8 genera to Orthopoxviruseg. Smallpox and Vaccinia
Unique Features of Poxviridae
· Largest family of viruses
· It can remain stable for hours in air

Genome
· Linear dsDNA covalently cross linked at ends
· Terminal repeated sequences
· Inverted repeats at both ends

Clinical Features
· It affects human only
· Respiratory secretions
· Always associated with skin lesions
· At least 9 poxviruses cause disease in human
· It takes 7 – 12 days incubation


Variola
· Smallpox from recipients to protect against future infection.

Cure
· Used cowpox from milkmaid
· Vaccinia used as a vector for vaccination





Eradication of smallpox
· No reservoir for smallpox virus except man
· Smallpox virus cause only acute infection from which the patients dies, or obtains lifelong immunity
· Smallpox virus is an effective immunogen

Lab diagnosis
· Not infectious during incubation but during symptoms
· Aerosol or air droplets
· Best defence is vaccination

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2:59 AM